Vitamin A Compound May Fight Colon Cancer

Vitamin A may play a role in suppressing colon cancer. In a new study, researchers found that boosting levels of retinoic acid (a compound derived in the body from vitamin A) in the intestines of mice with colon cancer slowed progression of the disease. Additionally, researchers found that colon cancer patients who had high levels of a protein that reduces retinoic acid in their intestinal tissue were more likely to have worse outcomes than other patients. Senior author Dr. Edgar Engleman adds, “Now that we’ve shown a role for retinoic acid deficiency in colorectal cancer, we’d like to identify the specific microorganisms that initiate these changes in humans. Ultimately we hope to determine whether our findings could be useful for the prevention or treatment of colorectal cancer.” Immunity, August 2016