In this study, researchers found that six hours of sleep deprivation led to elevated blood glucose in the liver, an increase in triglyceride levels, and changes to levels of liver enzymes related to metabolism in otherwise healthy rats. The research team believes that the changes induced by sleep deprivation may be the root cause of insulin resistance and buildup of fat in the liver, increasing the risk for diabetes, regardless of changes in activity and diet. American Journal of Physiology: Endocrinology and Metabolism, July 2018