According to a study that included over 1,200 participants, half of whom have a history of mental illness, individuals with bipolar disorder, anxiety, major depression, anorexia, and schizophrenia exhibit altered brain activity in a region of the brain called the dorsal mid-insula, which helps manage how the body senses internal sensations like pain, hunger, and the need to use the restroom. American Journal of Psychiatry, June 2021