New research indicates a relationship between a greater waist size and lower levels of brain-derived neurotrophic factor (BDNF)—a protein that supports the survival of existing neurons in the brain and encourages the growth and development of new neurons and synapses—that may hasten the development of dementia and other cognitive disorders. While it’s unclear how central adiposity influences BDNF, researchers suspect engaging in BDNF-promoting behaviors like regular exercise and eating a healthier diet may protect the brain function of adults with a larger waist circumference.
Journal of the International Neuropsychological Society, May 2016