Tobacco products that heat but do not burn tobacco to release a tobacco-flavored vapor that contains nicotine are marketed as a substitute for e-cigarettes or traditional cigarettes. An analysis of nearly 50 human and rodent studies showed that such inhalants were associated with high blood pressure, reduced dilation of blood vessels, stiffening of arteries, increased heart rate, and reduced heart function. American Journal of Physiology-Heart and Circulatory Physiology, October 2020